IS PENTRAXIN-3 STRONGER THAN C-REACTIVE PROTEIN TO DETERMINE INFLAMMATION IN PERITONEAL DIALYSIS PATIENTS?
Date
2012Author
Koldas, M.
Uzun, S.
Doventas, Y.
Sumnu, A.
KAZANCIOĞLU, Rümeyza
Gursu, M.
Ozturk, Savaş
Aydin, Z.
Karadag, S.
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Show full item recordAbstract
Pentraxin-3 (PTX-3) is the prototype of long pentraxins and is produced by many tissues and organs including vascular endothelial cells in response to pro-inflammatory signals. It is thought to be an independent indicator of disease activity. We analyzed the correlation of PTX-3 with other markers of inflammation in peritoneal dialysis (PD) patients. Non-diabetic patients on chronic PD program who meet the dialysis adequacy criteria and who had no active infectious/inflammatory disease were included. Demographic and clinical parameters were recorded as well as hsCRP, fibrinogen, interleukin-6 (IL-6) and PTX-3 levels; and the correlation between them were studied. Twenty-five patients (mean age: 45.7 +/- 12.5 years; female/male ratio: 16/9) were included. Mean PTX-3 level was 2.16 +/- 2.76ng/ml. PTX-3 was found to be correlated positively with only IL-6 among inflammatory markers (r=0.827; p<0.001) but not with hsCRP. With linear regression model, IL-6 was the only independent determinant of PTX-3 levels. PTX-3 may be a more valuable marker of inflammation than CRP in patients on PD.
URI
http://hdl.handle.net/20.500.12627/167687https://doi.org/10.1177/1721727x1201000305
https://avesis.istanbul.edu.tr/api/publication/9172afe5-2f29-463c-b797-6012d9e9a628/file
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