Prognostic Value of Baseline Neutrophil-to-Lymphocyte Ratio in Metastatic Urothelial Carcinoma Patients Treated With First-line Chemotherapy: A Large Multicenter Study

Date
2017
Author
Culine, Stephane
Caty, Armelle
Dujardin, Charlotte
Auclin, Edouard
Thibaut, Constance
Combe, Pierre
Tartour, Eric
Oudard, Stephane
Guven, Sermin
Ozguroglu, Mustafa
Auvray, Marie
Elaidi, Reza
Gauthier, Helene
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Abstract
This multicenter study assessed the prognostic value of the neutrophile-to-lymphocyte ratio (NLR), a biomarker of systemic inflammation, for overall survival (OS) and progression-free survival (PFS) after first-line chemotherapy (CT) in 280 metastatic urothelial cancer patients. High pre-CT NLR was an independent predictor of reduced of OS (hazard ratio=1.36; P<.0001), highlighting the importance of an inflammatory cancer-related microenvironment.
URI
http://hdl.handle.net/20.500.12627/164089
https://doi.org/10.1016/j.clgc.2016.10.013
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