Cytokine Contents in Chronic Lymphocytic Leukemia: Association with ZAP70 Expression
Date
2016Author
Cinar, Suzan
Isiksacan, Nilgun
Aktan, Melih
Deniz, Gunnur
Cetin, Esin
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Objective: Chronic lymphocytic leukemia (CLL) is a disease that shows varying clinical progression, and expression of the protein tyrosine kinase ZAP70 has been described as a very valuable prognostic factor. Patients with ZAP70 positivity are characterized by worse clinical course and significantly shorter progression-free and overall survival. In this study, intracytoplasmic interferon gamma (IFN-gamma) and interleukin-4 (IL-4) content of T, B, and CLL cells in CLL patients and their correlations with Rai staging and ZAP70 positivity were investigated.
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