Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the In vivo Elimination of Methotrexate and its Main Toxic Metabolite 7-hydroxymethotrexate

Date
2008
Author
Elferink, Ronald P. J. Oude
Pala, Zeliha
de Waart, Dirk R.
van de Wetering, Koen
Schinkel, Alfred H.
Vlaming, Maria L. H.
van Esch, Anita
Wagenaar, Els
van Tellingen, Olaf
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Abstract
Purpose: ATP-binding cassette sub-family C member 2 [ABCC2; multidrug resistance associated protein 2 (MRP2)] and ABCC3 (MRP3) mediate the elimination of toxic compounds, such as drugs and carcinogens, and have a large overlap in substrate specificity. We investigated the roles of Abcc2 and Abcc3 in the elimination of the anticancer drug methotrexate (MTX) and its toxic metabolite 7-hydroxymethotrexate (7OH-MTX) in vivo.
URI
http://hdl.handle.net/20.500.12627/163626
https://doi.org/10.1158/1078-0432.ccr-08-1609
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