Early response to immunosuppressive therapy predicts good renal outcome in lupus nephritis lessons from long-term followup of patients in the Euro-Lupus Nephritis Trial - Lessons from long-term followup of patients in the Euro-Lupus Nephritis Trial
Tarih
2004Yazar
BLOCKMANS, D
HOUSSIAU, FA
VASCONCELOS, C
D'CRUZ, D
SEBASTIANI, GD
GARRIDO, ED
DANIELI, MG
ABRAMOVICZ, D
MATHIEU, A
DIRESKENELI, H
GALEAZZI, M
LEVY, Y
PETERA, P
POPOVIC, R
PETROVIC, R
SINICO, RA
CATTANEO, R
FONT, J
DEPRESSEUX, GV
COSYNS, JP
CERVERA, R
Gul, Ahmet
Üst veri
Tüm öğe kaydını gösterÖzet
Objective. In the Euro-Lupus Nephritis Trial (ELNT), 90 patients with lupus nephritis were randomly assigned to a high-dose intravenous cyclophosphamide (IV CYC) regimen (6 monthly pulses and 2 quarterly pulses with escalating doses) or a low-dose IV CYC regimen (6 pulses of 500 mg given at intervals of 2 weeks), each of which was followed by azathioprine (AZA). After a median followup of 41 months, a difference in efficacy between the 2 regimens was not observed. The present analysis was undertaken to extend the followup and to identify prognostic factors.
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