PENETRATION OF CIPROFLOXACIN INTO PLEURAL FLUID
Tarih
1993Yazar
KESKINER, N
YILDIRIM, N
SIPAHIOGLU, B
HASAN, A
BARLAS, A
SOZER, K
OZUNER, Z
UMUT, S
DEMIR, T
AKKAN, G
YILMAZ, V
Üst veri
Tüm öğe kaydını gösterÖzet
The penetration of oral 1000 mg/day ciprofloxacin into pleural fluid is investigated in 15 patients with exudative pleural effusion. After 4 days of ciprofloxacin therapy ciprofloxacin concentrations were measured in plasma and pleural exudate simultaneously by high-performance liquid chromatography (HPLC). Mean serum ciprofloxacin level was 1.58 +/- 0.91 mg/L and mean pleural exudate concentration was 1.00 +/- 0.59 mg/L. The concentrations achieved were all above the MIC90 of the majority of Gram-positive and Gram-negative pathogens. It is concluded that ciprofloxacin penetrates well into the pleural fluid.
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