Treatment of Clarithromycin-Induced Rhabdomyolysis with Continuous Renal Replacement Therapy

Abstract

Rhabdomyolysis is a rare, life-threatening syndrome characterized by a diffuse and severe muscle injury. Clinical presentation is variable, ranging from asymptomatic disease to acute renal failure. Clarithromycin, a commonly used macrolide antibiotic, can cause rhabdomyolysis by inhibiting CYP450 enzyme system. Rhabdomyolysis related to combination of macrolide and statins has been previously reported in adults. However, it is rare in children, especially with clarithromycin monotherapy. Herein we report our experience with a severe rhabdomyolysis and acute renal failure following clarithromycin administration in a 8-year-old patient.