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dc.contributor.authorNeyts, Johan
dc.contributor.authorGürsoy, Aysel
dc.contributor.authorPaeshuyse, Jan
dc.contributor.authorDe Clercq, Erik
dc.contributor.authorKarali, Nilgün Lütfiye
dc.contributor.authorTerzioğlu, Nalan
dc.contributor.authorPannecouque, Christophe
dc.contributor.authorLeysen, Pieter
dc.date.accessioned2021-03-06T11:11:41Z
dc.date.available2021-03-06T11:11:41Z
dc.identifier.citationTerzioğlu N., Karali N. L. , Gürsoy A., Pannecouque C., Leysen P., Paeshuyse J., Neyts J., De Clercq E., "Synthesis and primary antiviral activity evaluation of 3-hydrazono-5-nitro-2-indolinone derivatives", ARKIVOC, ss.109-118, 2006
dc.identifier.issn1551-7004
dc.identifier.othervv_1032021
dc.identifier.otherav_eddf0447-d23d-4c51-b928-347971851dc8
dc.identifier.urihttp://hdl.handle.net/20.500.12627/156167
dc.identifier.urihttps://doi.org/10.3998/ark.5550190.0007.113
dc.description.abstractA series of 5-nitro-3-[(5-nonsubstituted/methyl-4-thiazolidinone-2-ylidene)hydrazono]-1H-2-indolinones (3a-j and 4a-h) was synthesized by cyclization of 5-nitro-1H-indole-2,3-dione-3-thiosemicarbazones (1a-k) with ethyl bromoacetate or ethyl 2-bromopropionate. The primary antiviral activities of the new hydrazonoindolinone derivatives, the previously reported 5-nitro-1H-indole-2,3-dione-3-thiosemicarbazones (1a-k) and 1-morpholino/piperidinomethyl-5-nitroindole-2,3- dione-3-thiosemicarbazones (2a-l) were evaluated against some pathogenic viruses in the Rega Institue for Medical Research, Belgium. Among the tested compounds, 1c, 2b and 3b afforded some weak activity against the yellow fever virus (YFV) in vero cells, whereas compounds 2b, 3a, 3f, 4e and 4f inhibited the growth of bovine viral diarrhea virus ( BVDV) in MDBK CODA cells.
dc.language.isoeng
dc.subjectBiyoinorganik Kimya
dc.subjectTemel Bilimler
dc.subjectBiyokimya
dc.subjectTemel Bilimler (SCI)
dc.subjectKimya
dc.subjectKİMYA, ORGANİK
dc.titleSynthesis and primary antiviral activity evaluation of 3-hydrazono-5-nitro-2-indolinone derivatives
dc.typeMakale
dc.relation.journalARKIVOC
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.startpage109
dc.identifier.endpage118
dc.contributor.firstauthorID47657


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