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Synthesis and primary antiviral activity evaluation of 3-hydrazono-5-nitro-2-indolinone derivatives

Author
Neyts, Johan
Gürsoy, Aysel
Paeshuyse, Jan
De Clercq, Erik
Karali, Nilgün Lütfiye
Terzioğlu, Nalan
Pannecouque, Christophe
Leysen, Pieter
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Abstract
A series of 5-nitro-3-[(5-nonsubstituted/methyl-4-thiazolidinone-2-ylidene)hydrazono]-1H-2-indolinones (3a-j and 4a-h) was synthesized by cyclization of 5-nitro-1H-indole-2,3-dione-3-thiosemicarbazones (1a-k) with ethyl bromoacetate or ethyl 2-bromopropionate. The primary antiviral activities of the new hydrazonoindolinone derivatives, the previously reported 5-nitro-1H-indole-2,3-dione-3-thiosemicarbazones (1a-k) and 1-morpholino/piperidinomethyl-5-nitroindole-2,3- dione-3-thiosemicarbazones (2a-l) were evaluated against some pathogenic viruses in the Rega Institue for Medical Research, Belgium. Among the tested compounds, 1c, 2b and 3b afforded some weak activity against the yellow fever virus (YFV) in vero cells, whereas compounds 2b, 3a, 3f, 4e and 4f inhibited the growth of bovine viral diarrhea virus ( BVDV) in MDBK CODA cells.
URI
http://hdl.handle.net/20.500.12627/156167
https://doi.org/10.3998/ark.5550190.0007.113
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Creative Commons Lisansı

İstanbul Üniversitesi Akademik Arşiv Sistemi (ilgili içerikte aksi belirtilmediği sürece) Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

DSpace software copyright © 2002-2016  DuraSpace
Contact Us | Send Feedback
Theme by 
Atmire NV