The Effects of D-Ala(2), D-Leu(5)-Enkephalin (DADLE)'s Continuous Perfusion on Erythrogram and Biochemical Profile in Rats

Abstract

In this experimental study it was aimed to investigate the effects of chronic continuous DADLE administration on erythrogram and the biochemical profile (ALP, ALT, AST, LDH, glucose, urea, creatinine, albumin, total protein). The study was carried on 48 adult male Wistar rats. DADLE was administered via osmotic mini-pumps, implanted subcutaneously. After the 28-day treatment, plasma glucose levels increased and urea levels decreased significantly in experimental group animals compared to the control group. Differences between the groups were not found to be statistically significant with respect to the other investigated parameters. So we conclude that chronic continuous administration of DADLE via osmotic mini-pumps did not exert any detrimental effect on erythrogram and the biochemical profile in rats.