Association of Serum Soluble Urokinase Receptor Levels With Progression of Kidney Disease in Children

Date
2017
Author
Smoyer, William
Yilmaz, Alev
SEVER, Sanja
REISER, Jochen
DUSEK, Jiri
SCHAEFER, Franz
Trachtman, Howard
WUHL, Elke
KIRCHNER, Marietta
Hayek, Salim S.
Anarat, Ali
KLAUS, Gunter
Jankauskiene, Augustina
WYGODA, Simone
GELLERMANN, Jutta
MATTEUCCI, Maria Chiara
OH, Jun
LITWIN, Mieczyslaw
ARBEITER, Klaus
LUGANI, Francesca
DÜZOVA, ALİ
Mir, Sevgi
PARIPOVIC, Dusan
TESTA, Sara
ZUROWSKA, Aleksandra
AFONSO, Alberto Caldas
TRACY, Melissa
WEI, Changli
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Abstract
IMPORTANCE Conventional methods to diagnose and monitor chronic kidney disease (CKD) in children, such as creatinine level and cystatin C-derived estimated glomerular filtration rate (eGFR) and assessment of proteinuria in spot or timed urine samples, are of limited value in identifying patients at risk of progressive kidney function loss. Serum soluble urokinase receptor (suPAR) levels strongly predict incident CKD stage 3 in adults.
URI
http://hdl.handle.net/20.500.12627/15479
https://doi.org/10.1001/jamapediatrics.2017.2914
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