NEOADJUVANT CHEMOTHERAPY AND RADIOTHERAPY IN LOCALLY ADVANCED UNDIFFERENTIATED NASOPHARYNGEAL CARCINOMA

Abstract

Twenty one patients with nonmetastatic locally advanced undifferentiated nasopharyngeal carcinoma were treated with chemotherapy and radiotherapy. According to TNM staging 8 patients had T4 and 16 patients (80%) had N2 or N3 disease.Two courses of Cisplatinum (P) and 5 Fluorouracil (F) chemotherapy were given before and also after radiation therapy. P was given 20 mg/m2, for 5 days as 30 minutes infusion and F was given 600 mg/m2, for 5 days as 24 hours continous infusion. Co-60 radiotherapy was given as 46 Gy to the primary lesions and upper cervical region, 50 Gy to the lower cervical region, 50 Gy to the lower cervical and bilateral supraclavicular regions.