Association of APOE polymorphisms with disease severity in MS is limited to women
Tarih
2004Yazar
de Andrade, M
Weinshenker, BG
Atkinson, EJ
McMurray, CT
Rodriguez, M
Kantarci, OH
Hebrink, DD
Achenbach, SJ
Pittock, SJ
Altintas, A
Schaefer-Klein, JL
Üst veri
Tüm öğe kaydını gösterÖzet
The authors studied the association of an exon 4 (E4* epsilon2/3/4) and three promoter polymorphisms of APOE with disease course and severity stratified by gender in 221 patients with multiple sclerosis from two overlapping population-based prevalence cohorts. Women carriers of the E4* epsilon2 allele took longer to attain an Expanded Disability Status Scale score of 6 ( p = 0.015) and had more favorable ranked severity scores than noncarriers ( p = 0.009). There was no association in men. Alleles epsilon3 or epsilon4 and promoter polymorphisms were not associated with disease course or severity.
Bağlantı
http://hdl.handle.net/20.500.12627/146899https://doi.org/10.1212/01.wnl.0000113721.83287.83
Koleksiyonlar
- Makale [92796]