THE TWO-WAY RELATIONSHIP BETWEEN OBESITY AND PERIODONTITIS

Abstract

Periodontitis and obesity are two chronic inflammatory diseases. Since obesity and periodontitis are associated with systemic inflammation, these two situations are linked by common pathophysiology. TNF-alfa and IL-6 are cytokines that are involved in the pathophysiology of both obesity and periodontitis. The levels of these cytokines increase with obestiy and periodontitis. Resistin is produced by immune cells and therefore, is related to the activation of inflammatory processes. Increased resistin serum levels have been associated with periodontitis. Adipose tissues also secrete some antiinflammatory factors, such as adiponectin. Plasma levels of adiponectin are decreased in individuals who are obese, compared with persons who are normal weight. Furthermore, evidence suggests a trend toward decreased adiponectin serum levels and reduced adiponectin function in individuals with periodontitis. In conclusion, periodontitis and obesity are diseases that are associated through various cytokines, proteins, vitamins, etc.