A Possible Role for WNT5A Hypermethylation in Pediatric Acute Lymphoblastic Leukemia

Author
Yildirmak, Ytldiz
Firtina, Sinem
Karakas, Zeynep
Timur, Cetin
Sayitoglu, Muge
Ng, Ozden Hatirnaz
Can, Ismail
Agaoglu, Leyla
Dogru, Omer
Celkan, Tiraje
Akcay, Arzu
Ozbek, Ugur
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Abstract
Objective: WNT5A is one of the most studied noncanonical WNT ligands and is shown to be deregulated in different tumor types. Our aim was to clarify whether hypermethylation might be the cause of low WNT5A mRNA levels and whether we could restore this downregulation by reversing the event.
URI
http://hdl.handle.net/20.500.12627/142714
https://doi.org/10.4274/tjh.2013.0296
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