Association of PARP-1, NF-kappa B, NF-kappa BIA and IL-6, IL-beta 3 and TNF-alpha with Graves Disease and Graves Ophthalmopathy

Abstract

Background: Graves Disease (GD) is an autoimmune disorder affected by an interaction of multiple genes such as Nuclear Factor-kappa B (NF-kappa B), Nuclear Factor-kappa B Inhibitor (NF-kappa BIA), Poly (ADP-ribose) polymerase-1 (PARP-1) and cytokines like Interleukin-1 beta (IL-1 beta), Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-alpha) and mostly accompanied by an ocular disorder, Graves Ophthalmopathy (GO). We hypothesize that there is a relationship between GD, GO, polymorphisms of inflammatory related genes and their association with cytokines, which may play important roles in autoimmune and inflammatory processes.