Protective effect of a nuclear factor kappa B inhibitor, pyrolidium dithiocarbamate, in the kidney of rats with nephrolithiasis induced by ethylene glycol

Abstract

Purpose: To study the protective effects of a selective nuclear factor kappa B (NF-kappa B) inhibitor, pyrolidium dithiocarbamate (PDTC), on ethylene glycol-induced crystal deposition in the renal tubules, renal toxicity, as well as inducible nitric oxide synthase (iNOS) and NF-kappa B activities in rat kidneys.