Haemodiafiltration does not lower protein-bound uraemic toxin levels compared with haemodialysis in a paediatric population

Date
2020
Author
Saoussen, Krid
Litwin, Mieczyslaw
Obrycki, Lukasz
Paglialonga, Fabio
Ranchin, Bruno
Samaille, Charlotte
Schaefer, Franz
Schmitt, Claus Peter
Spasojevic, Brankica
Stefanidis, Constantinos J.
Shroff, Rukshana
Eloot, Sunny
Snauwaert, Evelien
Van Biesen, Wim
Raes, Ann
Glorieux, Griet
Vande Walle, Johan
Roels, Sanne
Vanholder, Raymond
Askiti, Varvara
Azukaitis, Karolis
KARABAY BAYAZIT, AYSUN
CANPOLAT, Nur
Fischbach, Michel
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Abstract
Background. Haemodiafiltration (HDF) is accepted to effectively lower plasma levels of middle molecules in the long term, while data are conflicting with respect to the additive effect of convection on lowering protein-bound uraemic toxins (PBUTs). Here we compared pre-dialysis beta 2-microglobulin (beta 2M) and PBUT levels and the percentage of protein binding (%PB) in children on post-dilution HDF versus conventional high- (hf) or low-flux (lf) haemodialysis (HD) over 12 months of treatment.
URI
http://hdl.handle.net/20.500.12627/137630
https://doi.org/10.1093/ndt/gfz132
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