Trigeminal somatosensorial evoked potentials suggest increased excitability during interictal period in patients with long disease duration in migraine

Abstract

Introduction: Migraine pathogenesis is suggested to involve many structures in cerebral cortex, brain stem and trigeminovascular system. Electrophysiological studies revealed loss of habituation, decreased cortical preactivation, segmental hypersensitivity and reduction in control of inhibitory descending pathways. Given these information, we aimed to evaluate the excitability changes of the trigeminal pathway in the cortex and brainstem in migraine using trigeminal nerve somatosensory evoked potentials (TSEP).