FIBRONECTIN AND SIALIC-ACID LEVELS IN HUMAN MENINGIOMAS AND GLIOMAS

Abstract

In this study, fibronectin and sialic acid levels have been assayed in human meningiomas and gliomas. The mean fibronectin and sialic acid levels for human meningiomas were 22.01 +/- 9.70 mu g/mg protein and 19.58 +/- 4.89 mu g/mg protein, respectively, and for human gliomas were 27.30 +/- 13.70 mu g/mg protein and 25.67 +/- 11.60 mu g/mg protein, respectively, versus 9.23 +/- 5.40 mu g/mg protein and 13.50 +/- 4.30 mu g/mg protein for normal brain tissues. Fibronectin and sialic acid levels were significantly higher in human meningiomas (P < 0.01 and P < 0.05) and gliomas (P < 0.001 and P < 0.01) than control group. Also the mean fibronectin and sialic acid levels were found to be 18.27 +/- 7.08 mu g/mg protein and 17.04 +/- 6.25 mu g/mg protein in Grade I-II and 32.60 +/- 15.00 mu g/mg protein ad 29.50 +/- 11.60 mu g/mg protein in Grade III-IV gliomas, respectively. Fibronectin and sialic acid levels were significantly higher in Grade III-IV gliomas than Grade I-II gliomas (P < 0.05).