TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport

Author
King, Stephen M.
Mans, Dorus A.
Ueffing, Marius
Krakow, Deborah
Beales, Philip L.
Al-Gazali, Lihadh
Wicking, Carol
Cormier-Daire, Valerie
Roepman, Ronald
Mitchison, Hannah M.
Witman, George B.
Huber, Celine
Boldt, Karsten
Patel, Mitali
van Reeuwijk, Jeroen
Plaza, Jean-Marc
van Beersum, Sylvia E. C.
Yap, Zhi Min
Letteboer, Stef J. F.
Taylor, S. Paige
Herridge, Warren
Johnson, Colin A.
Scambler, Peter J.
Kayserili, Hulya
Schmidts, Miriam
Hou, Yuqing
Cortes, Claudio R.
Metadata
Show full item record
Abstract
The analysis of individuals with ciliary chondrodysplasias can shed light on sensitive mechanisms controlling ciliogenesis and cell signalling that are essential to embryonic development and survival. Here we identify TCTEX1D2 mutations causing Jeune asphyxiating thoracic dystrophy with partially penetrant inheritance. Loss of TCTEX1D2 impairs retrograde intraflagellar transport (IFT) in humans and the protist Chlamydomonas, accompanied by destabilization of the retrograde IFT dynein motor. We thus define TCTEX1D2 as an integral component of the evolutionarily conserved retrograde IFT machinery. In complex with several IFT dynein light chains, it is required for correct vertebrate skeletal formation but may be functionally redundant under certain conditions.
URI
http://hdl.handle.net/20.500.12627/136547
https://doi.org/10.1038/ncomms8074
Collections