Constituents of Salvia microphylla

Abstract

A new phenolic ester 2-(p-hydroxyphenyl) ethyl eicosaheptanoic acid ester ( 1) and a known one hexacosylferulate ( 2) were isolated from the acetone extract of Salvia microphylla. In addition, two sesquiterpenes beta-eudesmol ( 3) and 8 alpha-hydroxy-beta-eudesmol ( 4), a diterpene carnosic acid 12-methyl ether (12-methoxycarnosic acid) ( 5), three triterpenes erithrodiol 3-acetate, oleanolic acid, lupeol and beta-sitosterol were obtained as known compounds from this plant extract. The structures of the isolated compounds were elucidated by spectroscopic methods, including one- and two-dimensional H-1- and C-13-NMR and MS spectroscopies. The selected compounds were tested for antimicrobial activity against standard bacterial strains, and only carnosic acid 12-methyl ether showed antimicrobial activity against S. aureus at 78 mu g mL(-1).