Effects of 2,4-dichlorophenoxyacetic acid (2,4-D) on serum glucose level and kidney function activities in subchronically exposed rats

Abstract

The object of this study was to analyze the renal and pancreatic effects of the herbicide 2,4-D in Sprague-Dawley (CD) rats. Animals were treated with drinking water and food or 25, 50, 100 ppm of 2,4-D during 30 days. Sub-chronic treatment of animals induced in the highest dose (treated with 100 ppm 2,4-D in food) group a significant increase in the serum glucose level. We observed the increase in serum urea levels in groups treated with 50 ppm and 100 ppm herbicide in food but, these differences were not statistically important. The serum creatinin activity was at a similar level with the control group after 2,4-D exposure for 30 days.