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Early renal injury after myeloablative allogeneic and autologous hematopoietic cell transplantation

Date
2006
Author
Sargin, D.
Caliskan, Y.
Besisik, Sevgi
Ecder, T.
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Abstract
Renal insufficiency is a common complication early after hematopoietic stem cell transplantation ( HSCT). Renal function as measured by creatinine clearance (CrCl) was prospectively evaluated in 47 patients undergoing allogeneic (n = 22) or autologous (n = 25) HSCT during the first 100 days. Renal dysfunction was classified as follows: Grade 0 (= 25% decline in CrCl but = 2 x rise in serum creatinine but no need for dialysis) and Grade 3 (>= 2 x rise in serum creatinine and need for dialysis). Thirty-three patients (70%) had Grade 1-3 renal dysfunction. Renal dysfunction was more common after myeloablative allogeneic HSCT (91%) than autologous HSCT (52%) (P = 0.004), and was associated with a high risk of mortality (P = 0.039). Sepsis in autologous HSCT patients and cyclosporine toxicity in allogeneic HSCT patients were associated with renal dysfunction. We conclude that autologous and allogeneic HSCT differ in the likelihood and causes of renal dysfunction.
URI
http://hdl.handle.net/20.500.12627/129467
https://doi.org/10.1038/sj.bmt.1705412
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33745757659&origin=inward
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Creative Commons Lisansı

İstanbul Üniversitesi Akademik Arşiv Sistemi (ilgili içerikte aksi belirtilmediği sürece) Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

DSpace software copyright © 2002-2016  DuraSpace
Contact Us | Send Feedback
Theme by 
Atmire NV