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Consensus definitions and application guidelines for control groups in cerebrospinal fluid biomarker studies in multiple sclerosis

Date
2013
Author
Kuhle, Jens
Frederiksen, Jette L.
Galimberti, Daniela
Gnanapavan, Sharmilee
Hegen, Harald
Hemmer, Bernhard
Hintzen, Rogier
Hughes, Steve
Iacobaeus, Ellen
Kroksveen, Ann C.
Richert, John
Altintas, Ayse
Teunissen, Charlotte
Menge, Til
Alvarez-Cermeno, Jose C.
Bertolotto, Antonio
Berven, Frode S.
Brundin, Lou
Comabella, Manuel
Degn, Matilde
Deisenhammer, Florian
Bartos, Ales
Khalil, Michael
Dujmovic, Irena
Drulovic, Jelena
Villar, Luisa M.
Tumani, Hayrettin
Fazekas, Franz
Franciotta, Diego
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Abstract
The choice of appropriate control group(s) is critical in cerebrospinal fluid (CSF) biomarker research in multiple sclerosis (MS). There is a lack of definitions and nomenclature of different control groups and a rationalized application of different control groups. We here propose consensus definitions and nomenclature for the following groups: healthy controls (HCs), spinal anesthesia subjects (SASs), inflammatory neurological disease controls (INDCs), peripheral inflammatory neurological disease controls (PINDCs), non-inflammatory neurological controls (NINDCs), symptomatic controls (SCs). Furthermore, we discuss the application of these control groups in specific study designs, such as for diagnostic biomarker studies, prognostic biomarker studies and therapeutic response studies. Application of these uniform definitions will lead to better comparability of biomarker studies and optimal use of available resources. This will lead to improved quality of CSF biomarker research in MS and related disorders.
URI
http://hdl.handle.net/20.500.12627/127544
https://doi.org/10.1177/1352458513488232
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Creative Commons Lisansı

İstanbul Üniversitesi Akademik Arşiv Sistemi (ilgili içerikte aksi belirtilmediği sürece) Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

DSpace software copyright © 2002-2016  DuraSpace
Contact Us | Send Feedback
Theme by 
Atmire NV