Antioxidant and Anticholinesterase Activity Evaluation of ent-Kaurane Diterpenoids from Sideritis arguta
Tarih
2009Yazar
Topcu, Guelacti
Boga, Mehmet
Ertas, Abduelselam
ÖZTÜRK, MEHMET
Üst veri
Tüm öğe kaydını gösterÖzet
The petroleum ether and acetone extracts of the aerial parts of Sideritis arguta afforded two new and six known diterpenoids with the ent-kaurane skeleton. The structures of the new diterpenoids were determined as ent-7 alpha,18-diacetoxy-16 beta-hydroxykaurane (diacetyidistanol) (1) and ent-7 alpha-acetoxy,15 alpha,18-dihydroxykaur-16-ene (15-epi-eubol) (2) by spectroscopic data interpretation. Antioxidant potential was investigated for the ent-kauranes and the plant extracts by three methods (beta-carotene bleaching, free-radical scavenging, and superoxide-anion scavenging activity). Acetylcholinesterase and butyrylcholinesterase inhibitory activity were also evaluated, and the ent-kauranes eubol (3), sideroxol (5), and 7-epi-candicandiol (6) exhibited moderate butyrylcholinesterase inhibitory activity.
Koleksiyonlar
- Makale [92796]