Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

Date
2012
Author
Witteman, Jacqueline C. M.
Jansson, John-Olov
Ohlsson, Claes
Tivesten, Asa
Ljunggren, Osten
Reilly, Muredach P.
Thomas, G. Neil
Boehnke, Michael
Schunkert, Heribert
Asselbergs, Folkert W.
Kastelein, John J. P.
Gudnason, Vilmundur
Salomaa, Veikko
Harris, Tamara B.
Kooner, Jaspal S.
Allin, Kristine H.
Nordestgaard, Borge G.
Hopewell, Jemma C.
Goodall, Alison H.
Ridker, Paul M.
Holm, Hilma
Watkins, Hugh
Ouwehand, Willem H.
Samani, Nilesh J.
Kaptoge, Stephen
Di Angelantonio, Emanuele
Harari, Olivier
Danesh, John
Onat, Altan
Chambers, John C.
Sarwar, Nadeem
Butterworth, Adam S.
Freitag, Daniel F.
Gregson, John
Willeit, Peter
Gorman, Donal N.
Gao, Pei
Saleheen, Danish
Rendon, Augusto
Nelson, Christopher P.
Braund, Peter S.
Hall, Alistair S.
Chasman, Daniel I.
Tybjaerg-Hansen, Anne
Benjamin, Emelia J.
Franks, Paul W.
Clarke, Robert
Wilde, Arthur A. M.
Trip, Mieke D.
Hamsten, Anders
Ingelsson, Erik
Cambien, Francois
Hung, Joseph
Steri, Maristella
Qi, Lu
van der Schoot, C. Ellen
de Faire, Ulf
Erdmann, Jeanette
Stringham, Heather M.
Koenig, Wolfgang
Rader, Daniel J.
Melzer, David
Reich, David
Psaty, Bruce M.
Kleber, Marcus E.
Panagiotakos, Demosthenes B.
Willeit, Johann
Wennberg, Patrik
Woodward, Mark
Adamovic, Svetlana
Rimm, Eric B.
Meade, Tom W.
Gillum, Richard F.
Shaffer, Jonathan A.
Hofman, Albert
Sundstrom, Johan
Wassertheil-Smoller, Sylvia
Mellstrom, Dan
Gallacher, John
Cushman, Mary
Tracy, Russell P.
Kauhanen, Jussi
Karlsson, Magnus
Salonen, Jukka T.
Wilhelmsen, Lars
Amouyel, Philippe
Cantin, Bernard
Best, Lyle G.
Ben-Shlomo, Yoav
Manson, JoAnn E.
Davey-Smith, George
de Bakker, Paul I. W.
O'Donnell, Christopher J.
Wilson, James F.
Wilson, Anthony G.
Assimes, Themistocles L.
Metadata
Show full item record
Abstract
Background Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling.
URI
http://hdl.handle.net/20.500.12627/125343
https://doi.org/10.1016/s0140-6736(11)61931-4
Collections