Effect of TNF-α and IL-1β genetic variants on the development of myocardial infarction in Turkish population.

Abstract

Tumor necrosis factor-alpha (TNF-alpha) and interleukin 1 beta (IL-1 beta) genetic variants which resulting in TNF-alpha and IL-1 overproduction may increase susceptibility to autoimmune diseases such as atherosclerosis. We have studied the association of TNF-alpha G308A and IL-1 beta (+3953) C/T polymorphism with myocardial infarction in Turkish population. 143 patients with myocardial infarction and 213 age-matched healthy controls were included in the study. In univariant analysis, the frequencies of IL-1 beta, TNF-alpha genotype or allele, and haplotype of C:A and T:A were significantly elevated in patients when compared with those of controls. GA genotype of TNF-alpha, T allele of IL-1 beta and A of TNF-alpha allele seem to be risk factors for myocardial infarction. In contrast, CC genotype of IL-1 beta and GG genotype of TNF-alpha have protective effect against myocardial infarction. In multivariate logistic regression analysis, TNF-alpha A allele, gender and smoking were associated with myocardial infarction. In conclusion, we can state that TNF-alpha A allele might be associated with myocardial infarction.