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Postantibiotic effect of various antibiotics on Legionella pneumophila strains isolated from water systems

Date
2012
Author
Zeybek, Zuhal
Birteksoz-Tan, Ayşe Seher
Metadata
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Abstract
The postantibiotic effects (PAE) of azithromycin, clarithromycin, ciprofloxacin, and levofloxacin were investigated against Legionella pneumophila (L. pneumophila) strains isolated from several hot water systems of different buildings in Istanbul. Each strain in logarithmic phase of growth was exposed to concentrations of antibiotics equal to minimum inhibitory concentration (MIC) and 4x MIC for 1 h. Recovery periods of test cultures were evaluated after centrifugation using the viable counting method. The mean values of PAEs for the strains of L. pneumophila, azithromycin at a concentration equal to and 4 times of MIC values were found 1.75 +/- 0.28 h and 4.06 +/- 0.44 h, for clarithromycin 2.98 +/- 0.70 h and 4.18 +/- 0.95 h, for ciprofloxacin 2.97 +/- 0.63 h and 4.70 +/- 0.63 h, for levofloxacin 2.05 +/- 0.33 h and 3.78 +/- 0.46 h, respectively. All of the antibiotics showed increased PAE values in a concentration-dependent manner. The findings of our study may play useful role in selecting the appropriate timing of doses during therapy with antimicrobials to treat patients infected with L. pneumophila.
URI
http://hdl.handle.net/20.500.12627/12457
https://doi.org/10.1007/s12223-012-0161-2
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İstanbul Üniversitesi Akademik Arşiv Sistemi (ilgili içerikte aksi belirtilmediği sürece) Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

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Creative Commons Lisansı

İstanbul Üniversitesi Akademik Arşiv Sistemi (ilgili içerikte aksi belirtilmediği sürece) Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

DSpace software copyright © 2002-2016  DuraSpace
Contact Us | Send Feedback
Theme by 
Atmire NV