Collagen ultrastructure and TGF-beta 1 expression preserved with aminoguanidine during wound healing in diabetic rats

Abstract

Advanced glycoxidation end products have been implicated in delayed diabetic wound healing. In this study, we evaluated the effects of aminoguanidine, which is an advanced glycation and nitric oxide ( NO) synthase inhibitor, on extracellular matrix protein expression, collagen configuration, and nitrite/nitrate levels in wounds of diabetic rats.