Accounting for genetic heterogeneity in homozygosity mapping: application to Mendelian susceptibility to mycobacterial disease

Date
2011
Author
Al-Muhsen, Saleh
Casanova, Jean-Laurent
Abel, Laurent
Grant, Audrey V.
Boisson-Dupuis, Stephanie
Herquelot, Eleonore
de Beaucoudrey, Ludovic
Filipe-Santos, Orchidee
Camcioglu, Yildiz
Palanduz, Ayşe
Nolan, Daniel K.
Feinberg, Jacqueline
Boland, Anne
Sanal, Ozden
Kilic, Sara Sebnem
Bustamante, Jacinta
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Abstract
Introduction Genome-wide homozygosity mapping is a powerful method for locating rare recessive Mendelian mutations. However, statistical power decreases dramatically in the presence of genetic heterogeneity.
URI
http://hdl.handle.net/20.500.12627/120407
https://doi.org/10.1136/jmg.2011.089128
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