The Frequency of Sister Chromatid Exchanges in Patients with Crohn's Disease and the Effect of Therapy with "Anti-Tumor Necrosis Factor" on this Frequency

Abstract

Background/Aims: The analysis of sister chromatid exchanges (SCE), defined as symmetrical exchanges between sister chromatids in peripheral blood lymphocytes, has been used as an indicator of chromosomal instability. The study aimed to find out the frequency of sister chromatid exchanges in patients with Crohn's disease and to find the effect of therapy with anti-tumor necrosis factor (infliximab) on this frequency.