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Carbohydrate-deficient transferrin and sialidase levels in coronary heart disease

Date
2000
Author
Ulutin, T
Domanic, Nergiz
Sonmez, Hüseyin Avni
Kokoglu, Emine Hakkı
Ozturk, ZG
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Abstract
Transferrin is a N-glycosylated glycoprotein and plays an important role in iron transport from sites of absorption and storage to sites of utilization. The main component of normal serum transferrin contains two biantennary glycans, each consisting of 2 mol of sialic acid (Tetrasialo transferrin). Normal serum also contains small amounts of tri- and disialotransferrin, We have undertaken this study to investigate the levels of serum carbohydrate-deficient transferrin (Desialotransferrin) and sialidase levels in patients with coronary heart disease. In patient group, serum desialotransferrin and sialidase levels were found to be significantly higher than control group (p < 0.01 and p < 0.001, respectively), We conclude that increased activity of sialidase may be responsible for increased desialotransferrin in patients with coronary heart disease. Serum desialotransferrin levels map be useful critaria to diagnosis and pathogenesis of coronary heart disease. (C) 2000 Elsevier Science Ltd. All rights reserved.
URI
http://hdl.handle.net/20.500.12627/116017
https://doi.org/10.1016/s0049-3848(00)00262-0
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Creative Commons Lisansı

İstanbul Üniversitesi Akademik Arşiv Sistemi (ilgili içerikte aksi belirtilmediği sürece) Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

DSpace software copyright © 2002-2016  DuraSpace
Contact Us | Send Feedback
Theme by 
Atmire NV