Telomeric DNA: Marker for human prostate cancer development?
Tarih
1998Yazar
Chung , L.W.K.
ÖZEN, Mustafa
Narayanan , A.R.
von Eschenbach , A.C.
Pathak, S.
Imam, S.A.
Datar, R.H.
Multani , A.S.
Üst veri
Tüm öğe kaydını gösterÖzet
BACKGROUND. Telomeres that protect chromosomes at both ends are shortened with each somatic cell division through replication-dependent sequence loss at DNA termini. The chromosomes with shortened telomeres tend to become unstable, leading to cell death. Due largely to reactivation/upregulation of telomerase, a ribonucleoprotein that adds nucleotide sequences onto chromosome ends, cancer cells become immortal and neoplastically transformed.
Koleksiyonlar
- Makale [92796]