Promising link between selenium and peroxisome proliferator activated receptor gamma in the treatment protocols of obesity as well as depression

Abstract

Considerable interest has been given to the significance of peroxisome proliferator activated receptors (PPARs) in macronutrient metabolism, however, there is not sufficient data concerning the interactions between PPARs and micronutrients. Investigations performed on PPAR gamma and one of the essential micronutrients selenium (Se) have shown that both parameters may lead to alterations in obesity related or mood disorders. Therefore, it is plausible to consider PPAR gamma and Se together as a powerful combination during the treatment of two associated diseases; obesity and depression.