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dc.contributor.authorAbudayyak, M
dc.contributor.authorÖzhan, G
dc.contributor.authorBoran, T
dc.contributor.authorArici, M
dc.date.accessioned2021-03-05T10:02:35Z
dc.date.available2021-03-05T10:02:35Z
dc.identifier.citationArici M., Abudayyak M., Boran T., Özhan G., "Does pendimethalin develop in pancreatic cancer induced inflammation?", Chemosphere, cilt.252, ss.126644, 2020
dc.identifier.issn0045-6535
dc.identifier.othervv_1032021
dc.identifier.otherav_a0ff4732-7bca-41e7-b507-57612bbbcd6b
dc.identifier.urihttp://hdl.handle.net/20.500.12627/107943
dc.identifier.urihttps://doi.org/10.1016/j.chemosphere.2020.126644
dc.description.abstractPendimethalin, one of the dinitroaniline group herbicides, is applied for controlling weeds in cereals,legumes and vegetable crops, and has been classified as possible human carcinogen. It is indicated thatpendimethalin should arise risks of developing some cancer types; however, there is no data on theeffects of pendimethalin on pancreatic cancer-induced inflammation. Injuries resulting from by acutepancreatitis attacks and inflammation are significant factors in the development of pancreatic cancer.Therefore, we investigated whether pendimethalin triggers inflammation as a mechanism of pancreaticcancer development. Parameters related to pancreatic activation, oxidative stress, and inflammationwere measured in the human pancreatic (PANC-1) cell line. In the range of 0e100mM, the levels ofchymotrypsin decreased. It should be indicated that the reason for the decrease in chymotrypsin may bethe high rates of cell death (20%) observed in the high concentration levels. We observed that pendi-methalin significantly induced oxidative damage, while levels of interleukin-6 (IL-6) and interleukin-8(IL-8) did not change. The obtained results may draw attention to the usage and possible toxic effectof pendimethalin due to oxidative damage induction; however, detailed inflammation mechanisms andother cancer pathways should be investigated.
dc.language.isoeng
dc.subjectMeslek Bilimleri
dc.subjectFarmasötik Toksikoloji
dc.subjectToxicology
dc.subjectPharmacology
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectHealth, Toxicology and Mutagenesis
dc.subjectPharmacology (medical)
dc.subjectPharmacy
dc.subjectDrug Guides
dc.subjectPhysical Sciences
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectSağlık Bilimleri
dc.subjectTOKSİKOLOJİ
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectKlinik Tıp (MED)
dc.subjectEczacılık
dc.titleDoes pendimethalin develop in pancreatic cancer induced inflammation?
dc.typeMakale
dc.relation.journalChemosphere
dc.contributor.departmentİstinye Üniversitesi , ,
dc.identifier.volume252
dc.identifier.startpage126644
dc.identifier.endpage126644
dc.contributor.firstauthorID2486688


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