Does pendimethalin develop in pancreatic cancer induced inflammation?

Abstract

Pendimethalin, one of the dinitroaniline group herbicides, is applied for controlling weeds in cereals,legumes and vegetable crops, and has been classified as possible human carcinogen. It is indicated thatpendimethalin should arise risks of developing some cancer types; however, there is no data on theeffects of pendimethalin on pancreatic cancer-induced inflammation. Injuries resulting from by acutepancreatitis attacks and inflammation are significant factors in the development of pancreatic cancer.Therefore, we investigated whether pendimethalin triggers inflammation as a mechanism of pancreaticcancer development. Parameters related to pancreatic activation, oxidative stress, and inflammationwere measured in the human pancreatic (PANC-1) cell line. In the range of 0e100mM, the levels ofchymotrypsin decreased. It should be indicated that the reason for the decrease in chymotrypsin may bethe high rates of cell death (20%) observed in the high concentration levels. We observed that pendi-methalin significantly induced oxidative damage, while levels of interleukin-6 (IL-6) and interleukin-8(IL-8) did not change. The obtained results may draw attention to the usage and possible toxic effectof pendimethalin due to oxidative damage induction; however, detailed inflammation mechanisms andother cancer pathways should be investigated.