Drug and Herb induced liver injury: a short review

Abstract

Chemical induced liver injury is a pathological condition caused by diver's medications and other xenobiotics, leading to deficiencies in liver functions with the elimination of other diagnosis. Liver injury is prevalent in the world and can result in serious clinical outcome and has possibly fatal outcome. Chemical induced liver injury has an estimated annual incidence 10-15 per 10,000-100,000 patients received several prescription medications. The kind of liver injury are almost 10% cases with acute hepatitis, and is the most common cause of acute liver failure in the United States. Also, liver injury appeared after approval for marketing has restricted the use of many drugs (e.g., isoniazid, labetalol, and felbamate). Therefore, especially drug-induced liver injury is currently the major reason for discontinuation of a new compound in development or for withdrawal of a successfully launched drug from the market. In this review, we researched that mechanisms of liver injury with drugs and herbal preparations, and potential risks have been reported.