The effect of CD14 and TLR4 gene polimorphisms on asthma phenotypes in adult Turkish asthma patients: a genetic study

Author
Kuskucu, Aysegul
Sahin, Fusun
Karaca, Nilgun
Yildiz, Pinar
Kuskucu, Mert Ahmet
Midilli, Kenan
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Abstract
Background: Endotoxins stimulate T helper 1 cell maturation and send a negative signal to T helper 2 polarisation. This causes a decrease IgE levels and prevents atopy (Hygiene hypothesis). It is shown that this response is under genetic control by polymorphisms in CD14 and TLR4 genes in some researchs. We aimed to investigate the effects of genetic variants of CD14 (-) and TLR4 (Asp299Gly, Thr399Ile) genes on asthma phenotypes in adults with asthma.
URI
http://hdl.handle.net/20.500.12627/107588
https://doi.org/10.1186/1471-2466-14-20
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