Variant Philadelphia translocations with different breakpoints in six chronic myeloid leukemia patients

Date
2011
Author
Soysal, Teoman
Eskazan, Ahmet Emre
Arguden, Yelda Tarkan
Ulku, Birsen
Hacihanefioglu, Seniha
Deviren, Ayhan
Ar, Muhlis Cem
Yilmaz, Sukriye
Kuru, Dilhan
Cirakoglu, Ayse
Ongoren, Seniz
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Abstract
Objective: The Philadelphia (Ph) chromosome, consisting of the t(9;22)(q34;q11) translocation, is observed in similar to 90% of patients with chronic myeloid leukemia (CML). Variant Ph translocations are observed in 5%-40% of CML patients. In variant translocations 3 and possibly more chromosomes are involved. Herein we report 6 CML patients with variant Ph translocations.
URI
http://hdl.handle.net/20.500.12627/105066
https://doi.org/10.5152/tjh.2011.52
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