Relationship of CTLA4 and CD28 polymorphisms with lung involvement, HRCT findings and pulmonary function tests in Turkish patients with ankylosing spondylitis

Date
2017
Author
Yakar, Fatih
UYSAL, ÖMER
Sozgen, Hatice
Ozkan, Nazli Ezgi
Akkoyunlu, Muhammet Emin
Bayram, Mehmet
Ozcelik, Hatice Kutbay
Guler, Mustafa
Kart, Levent
Sezer, Murat
Yaylim, Ilhan
OKYALTIRIK, FATMANUR
Rezvani, Aylin
Turan, Saime
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Abstract
Background and AimsAnkylosing spondylitis (AS) is a multisystem disorder with ocular, pulmonary, and cardiovascular involvement. The incidence of pulmonary involvement varies from 1 to 52%. Abnormal T-cell function-derived immune responses are involved in AS pathogenesis. Numerous genes such as CTLA4 and CD28 control T-cell functions. In this study, we aimed to address the relationship between CTLA4 and CD28 polymorphisms and lung involvement in Turkish patients with AS.
URI
http://hdl.handle.net/20.500.12627/103324
https://doi.org/10.1111/crj.12388
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