Is there any association between apolipoprotein E and angiotensin converting enzyme gene polymorphism in patients with Parkinson's disease and dementia in Turkish Population?

Abstract

The genetic factors which predispose individuals to dementia in old age have not been fully defined. The epsilon4 allele of the gene encoding apolipoprotein E (Apo E) is the only well replicated genetic risk factor for non-autosomal dominant forms of Alzheimer's disease (AD). Recent reports indicate that the Angiotensin Converting Enzyme (ACE) Deletion (D) polymorphism is associated with a high risk for coronary heart disease and may effect longevity/survival into old age. Since there is no study concerning polymorphism of the Apo E and ACE gene and dementia subtypes in Turkish population, we have examined the these polymorphism in patients with dementia and Parkinson's disease,