A replication study of JTC bias, genetic liability for psychosis and delusional ideation
Date
2022Author
Yalincetin, Berna
Akdede, Berna
Richards, Alexander L.
BİNBAY, İBRAHİM TOLGA
ALTINYAZAR, VESİLE
GÜMÜŞ AKAY, GÜVEM
CİHAN, BURÇİN
Soygur, Haldun
ULAŞ, HALİS
Cankurtaran, Eylem S.
Kaymak, Semra U.
Mihaljevic, Marina M.
Petrovic, Sanja S.
Mirjanic, Tijana
Bernardo, Miguel
Mezquida, Gisela
Amoretti, Silvia
Bobes, Julio
Saiz, Pilar A.
Garcia-Portilla, Maria P.
Sanjuan, Julio
Aguilar, Eduardo J.
Santos, Jose L.
Jimenez-Lopez, Estela
Arrojo, Manuel
Carracedo, Angel
Lopez, Gonzalo
Gonzalez-Penas, Javier
Parellada, Mara
Maric, Nadja P.
Atbasoglu, Cem
Ucok, Alp
Alptekin, Koksal
SAKA, MERAM CAN
Arango, Celso
O'Donovan, Michael
Rutten, Bart P. F.
Guloksuz, Sinan
Henquet, Cecile
van Os, Jim
Pries, Lotta K.
Rauschenberg, Christian
Delespaul, Philippe
Kenis, Gunter
Luykx, Jurjen J.
Lin, Bochao D.
Metadata
Show full item recordAbstract
Background This study attempted to replicate whether a bias in probabilistic reasoning, or 'jumping to conclusions'(JTC) bias is associated with being a sibling of a patient with schizophrenia spectrum disorder; and if so, whether this association is contingent on subthreshold delusional ideation. Methods Data were derived from the EUGEI project, a 25-centre, 15-country effort to study psychosis spectrum disorder. The current analyses included 1261 patients with schizophrenia spectrum disorder, 1282 siblings of patients and 1525 healthy comparison subjects, recruited in Spain (five centres), Turkey (three centres) and Serbia (one centre). The beads task was used to assess JTC bias. Lifetime experience of delusional ideation and hallucinatory experiences was assessed using the Community Assessment of Psychic Experiences. General cognitive abilities were taken into account in the analyses. Results JTC bias was positively associated not only with patient status but also with sibling status [adjusted relative risk (aRR) ratio : 4.23 CI 95% 3.46-5.17 for siblings and aRR: 5.07 CI 95% 4.13-6.23 for patients]. The association between JTC bias and sibling status was stronger in those with higher levels of delusional ideation (aRR interaction in siblings: 3.77 CI 95% 1.67-8.51, and in patients: 2.15 CI 95% 0.94-4.92). The association between JTC bias and sibling status was not stronger in those with higher levels of hallucinatory experiences. Conclusions These findings replicate earlier findings that JTC bias is associated with familial liability for psychosis and that this is contingent on the degree of delusional ideation but not hallucinations.
URI
http://hdl.handle.net/20.500.12627/188530https://avesis.istanbul.edu.tr/api/publication/4742f2e0-3e3c-4908-b238-dd9981e19278/file
https://doi.org/10.1017/s0033291720003578
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