Basit öğe kaydını göster

The effects of 17 beta-estradiol on blood brain barrier integrity in the absence of the estrogen receptor alpha; an in-vitro model

dc.contributor.authorKaptan, Zulal
dc.contributor.authorKuruca, Serap Erdem
dc.contributor.authorAkgun-Dar, Kadriye
dc.contributor.authorKaradenizli, Sabriye
dc.contributor.authorKapucu, Aysegul
dc.contributor.authorUzum, Gulay
dc.date.accessioned2021-03-05T07:26:36Z
dc.date.available2021-03-05T07:26:36Z
dc.identifier.citationKuruca S. E. , Karadenizli S., Akgun-Dar K., Kapucu A., Kaptan Z., Uzum G., "The effects of 17 beta-estradiol on blood brain barrier integrity in the absence of the estrogen receptor alpha; an in-vitro model", ACTA HISTOCHEMICA, cilt.119, ss.638-647, 2017
dc.identifier.issn0065-1281
dc.identifier.otherav_93cfe46c-e665-4fa3-9c36-5e68c3cd1d9b
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/99584
dc.identifier.urihttps://doi.org/10.1016/j.acthis.2017.07.005
dc.description.abstractThe blood-brain barrier (BBB), which saves the brain from toxic substances, is formed by endothelial cells. It is mainly composed of tight junction (TJ) proteins existing between endothelial cells. Estrogen is an important regulatory hormone of BBB permeability. It protects the BBB before menopause, but may increase BBB permeability with aging. In addition, nitric oxide modulates BBB permeability. Alcohol impairs the integrity of the BBB with oxidants and inflammatory mediators such as iNOS. We investigated the effects of estrogen on BBB integrity in an in vitro BBB model created with ER alpha-free HUVEC (human umbilical vein endothelial-like cells) to mimics the menopausal period.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectTemel Bilimler
dc.subjectTemel Tıp Bilimleri
dc.subjectHistoloji-Embriyoloji
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectHÜCRE BİYOLOJİSİ
dc.titleThe effects of 17 beta-estradiol on blood brain barrier integrity in the absence of the estrogen receptor alpha; an in-vitro model
dc.typeMakale
dc.relation.journalACTA HISTOCHEMICA
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume119
dc.identifier.startpage638
dc.identifier.endpage647
dc.contributor.firstauthorID1045028


Bu öğenin dosyaları:

DosyalarBoyutBiçimGöster

Bu öğe ile ilişkili dosya yok.

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster