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dc.contributor.authorSansoy, Vedat
dc.contributor.authorGuclu-Geyik, Filiz
dc.contributor.authorErginel-Unaltuna, Nihan
dc.contributor.authorCan, Gunay
dc.contributor.authorKomurcu-Bayrak, Evrim
dc.contributor.authorOnat, Altan
dc.contributor.authorCoban, NESLİHAN
dc.date.accessioned2021-03-04T19:53:17Z
dc.date.available2021-03-04T19:53:17Z
dc.date.issued2012
dc.identifier.citationGuclu-Geyik F., Onat A., Coban N., Komurcu-Bayrak E., Sansoy V., Can G., Erginel-Unaltuna N., "Minor allele of the APOA4 gene T347S polymorphism predisposes to obesity in postmenopausal Turkish women", MOLECULAR BIOLOGY REPORTS, cilt.39, ss.10907-10914, 2012
dc.identifier.issn0301-4851
dc.identifier.otherav_91eba6a9-d0d1-43e1-bcb4-297add09e107
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/98436
dc.identifier.urihttps://doi.org/10.1007/s11033-012-1990-4
dc.description.abstractThe aim of this study was to examine the relationship between APOA4 gene T347S polymorphism with obesity measures and serum lipids in Turkish adults. Randomly selected sample of 1,554 adults (754 men, mean age 50.4 +/- A 11.9 years and 800 women, mean age 49.6 +/- A 11.8 years) were included in the study. 346 Women (43.2 %) were postmenopausal. Genotyping was performed by using hybridization probes in real-time PCR. Not men but postmenopausal women, carrying the S347 allele, were associated with 1.5 kg/m(2) higher BMI (P = 0.016) and 3.6 cm wider waist circumference (P = 0.005) than postmenopausal T347 homozygotes, controlled for covariates. Logistic regression analyses of this polymorphism, adjusted for age, fasting triglyceride, smoking status, alcohol consumption and physical activity disclosed the rare allele to be associated with obesity in postmenopausal women at an odds of 1.80 (95 % CI 1.09-2.97; P = 0.021). Serum apoB level was lower in S347 allele carriers (110.9 +/- A 2.9 mg/dL) than in T347 homozygotes (119.0 +/- A 2.4 mg/dL; P = 0.035) in men but not women. APOA4 T347S polymorphism was unrelated to lipids and other lipoproteins in either gender. The APOA4 S347 allele predisposes to obesity and high waist circumference in Turkish postmenopausal women. ApoB levels are lower only in men in S347 allele carriers.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectSitogenetik
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.titleMinor allele of the APOA4 gene T347S polymorphism predisposes to obesity in postmenopausal Turkish women
dc.typeMakale
dc.relation.journalMOLECULAR BIOLOGY REPORTS
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume39
dc.identifier.issue12
dc.identifier.startpage10907
dc.identifier.endpage10914
dc.contributor.firstauthorID22


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