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dc.contributor.authorOzturk, Mehmet
dc.contributor.authorKILIÇ, TURGUT
dc.contributor.authorHalfon, Belkis
dc.contributor.authorDincel, Demet
dc.contributor.authorTopcu, Gulacti
dc.contributor.authorErtas, Abdulselam
dc.date.accessioned2021-03-04T19:24:33Z
dc.date.available2021-03-04T19:24:33Z
dc.date.issued2011
dc.identifier.citationTopcu G., Ertas A., Ozturk M., Dincel D., KILIÇ T., Halfon B., "Ent-kaurane diterpenoids isolated from Sideritis congesta", PHYTOCHEMISTRY LETTERS, cilt.4, ss.436-439, 2011
dc.identifier.issn1874-3900
dc.identifier.othervv_1032021
dc.identifier.otherav_8f9d5cc3-85a2-4921-92c4-4d22dbe7c650
dc.identifier.urihttp://hdl.handle.net/20.500.12627/96975
dc.identifier.urihttps://doi.org/10.1016/j.phytol.2011.05.001
dc.description.abstractA new ent-kaurane diterpenoid, together with eight known ent-kauranes, were isolated from the petroleum ether and acetone extracts of the whole plant of Sideritis congesta P. H. Davis & Hub.-Mor. and their structures were elucidated as the new compound ent-7 alpha-acetoxy-16 beta, 18-dihydroxy-kaurane (7-acetyldistanol) (1) and the known compounds ent-3 beta,7 alpha-dihydroxy, 18-acetoxy-15 beta,16 beta-epoxykaurane (epoxyisolinearol) (2), sideroxol (3), sideridiol (4), siderol (5), 7-epicandicandiol (6), foliol (7), linearol (8) and sidol (9). Characterization of compounds 1-9 was based on spectral analyses and comparison with reported data, particularly the new compound 1 was identified by 1D- and 2D-NMR and mass spectroscopic analyses. The antioxidant potential of the extracts, and also of the ent-kauranes except for 7, was investigated by three methods including beta-carotene bleaching method, free radical scavenging activity and superoxide anion scavenging activity. The anticholinesterase activity was also evaluated for the ent-kauranes except for 7, and most of the diterpenes exhibited weak acetylcholinesterase inhibitory activity. However, almost all diterpenes exhibited some inhibitory activity against butyrylcholinesterase; particularly, compounds 3 and 6 exhibited better BChE inhibitory activity than the standard compound galanthamine. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.
dc.language.isoeng
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectTarımsal Bilimler
dc.subjectZiraat
dc.subjectBitki Koruma
dc.subjectFitopatoloji
dc.subjectYaşam Bilimleri
dc.subjectBiyokimya
dc.subjectTemel Bilimler
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectTemel Bilimler (SCI)
dc.subjectKimya
dc.subjectKİMYA, TIP
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectBitki ve Hayvan Bilimleri
dc.subjectBİTKİ BİLİMLERİ
dc.titleEnt-kaurane diterpenoids isolated from Sideritis congesta
dc.typeMakale
dc.relation.journalPHYTOCHEMISTRY LETTERS
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume4
dc.identifier.issue4
dc.identifier.startpage436
dc.identifier.endpage439
dc.contributor.firstauthorID202722


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