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dc.contributor.authorAkgun, Y
dc.contributor.authorErturan, Zayre
dc.contributor.authorKiraz, Nuri
dc.contributor.authorAng, O
dc.date.accessioned2021-03-04T19:00:31Z
dc.date.available2021-03-04T19:00:31Z
dc.identifier.citationKiraz N., Ang O., Akgun Y., Erturan Z., "Phenotypic variation and antifungal susceptibility patterns of Candida albicans strains isolated from neutropenic patients", MYCOSES, cilt.43, ss.119-123, 2000
dc.identifier.issn0933-7407
dc.identifier.othervv_1032021
dc.identifier.otherav_8da5dd20-7785-44e0-96d1-aeec9c1683ff
dc.identifier.urihttp://hdl.handle.net/20.500.12627/95749
dc.identifier.urihttps://doi.org/10.1046/j.1439-0507.2000.00569.x
dc.description.abstractThe aim of this study was to investigate the relationship between phenotypes of Candida albicans strains isolated from clinical specimens and the susceptibility of the strains to three antifungal agents, fluconazole, amphotericin B and flucytosine. Oropharyngeal, gastrointestinal and urogenital tract specimens were collected from 122 neutropenic patients who had received no previous prophylactic treatment. Each of 122 C. albicans strains recovered was found to express one of the six phenotypes: smooth, fuzzy, irregular, star, ring and stipple. The mean minimum inhibitory concentrations (MICs) of fluconazole was consistently higher for C. albicans strains expressing the stipple phenotype. The mean MICs for the six phenotypes of C. albicans strains ranged between 1.22 and 7.94 mu g ml(-1) for fluconazole, 0.99 and 2.55 mu g ml(-1) for amphotericin B and 1.23 and 1.83 mu g ml(-1) for flucytosine. The antifungal susceptibility of the stipple phenotype requires attention, especially in patients who are clinically unresponsive to fluconazole chemotherapy or in cases of life-threatening C. albicans infections of immunocompromised hosts. Long-term use of fluconazole may explain the outcome of the resistant stipple phenotype.
dc.language.isoeng
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectDermatoloji
dc.subjectTarımsal Bilimler
dc.subjectZiraat
dc.subjectBitki Koruma
dc.subjectFitopatoloji
dc.subjectMikoloji
dc.subjectBitki ve Hayvan Bilimleri
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectMİKOLOJİ
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectDERMATOLOJİ
dc.titlePhenotypic variation and antifungal susceptibility patterns of Candida albicans strains isolated from neutropenic patients
dc.typeMakale
dc.relation.journalMYCOSES
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume43
dc.identifier.startpage119
dc.identifier.endpage123
dc.contributor.firstauthorID36106


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