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dc.contributor.authorDalay, Nejat
dc.contributor.authorYazici, Hülya
dc.contributor.authorAkisik, Elif
dc.date.accessioned2021-03-04T18:47:17Z
dc.date.available2021-03-04T18:47:17Z
dc.date.issued2011
dc.identifier.citationAkisik E., Yazici H., Dalay N., "ARLTS1, MDM2 and RAD51 gene variations are associated with familial breast cancer", MOLECULAR BIOLOGY REPORTS, cilt.38, ss.343-348, 2011
dc.identifier.issn0301-4851
dc.identifier.otherav_8c8c2ba5-781d-4ba6-bf71-54dc7a21b58d
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/95071
dc.identifier.urihttps://doi.org/10.1007/s11033-010-0113-3
dc.description.abstractGenetic factors that contribute to the risk of breast cancer are largely not known and association studies have revealed several genes with low penetrance risk alleles for breast cancer. Analysis of these genes may provide important information on the risk factors affecting carcinogenesis. Variations in the ARLTS1, RAD51 and MDM2 genes have been associated with increased risk of different cancer types but for breast cancer the results are not consistent. In this study we investigated the role of the allelic variants in candidate genes acting in the tumor suppressor, DNA repair and p53 pathways as risk factors for familial breast cancer in 147 patients displaying characteristics of familial disease. Presence of the polymorphic variants were investigated by amplification of the corresponding regions and restriction fragment length polymorphism analysis. Genotype and allele frequencies in the patients were significantly different for all three variants. Our results indicate that the polymorphic variants might affect individual susceptibility towards breast cancer.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectSitogenetik
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.titleARLTS1, MDM2 and RAD51 gene variations are associated with familial breast cancer
dc.typeMakale
dc.relation.journalMOLECULAR BIOLOGY REPORTS
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume38
dc.identifier.issue1
dc.identifier.startpage343
dc.identifier.endpage348
dc.contributor.firstauthorID57218


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