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Evidence of linkage disequilibrium between polymorphisms at the IRF6 locus and isolate tooth agenesis, in a Turkish population

dc.contributor.authorMENEZES, Renato
dc.contributor.authorSeymen, Figen
dc.contributor.authorPatir, Asli
dc.contributor.authorVIEIRA, Alexandre R.
dc.date.accessioned2021-03-04T18:01:16Z
dc.date.available2021-03-04T18:01:16Z
dc.date.issued2008
dc.identifier.citationVIEIRA A. R. , Seymen F., Patir A., MENEZES R., "Evidence of linkage disequilibrium between polymorphisms at the IRF6 locus and isolate tooth agenesis, in a Turkish population", ARCHIVES OF ORAL BIOLOGY, cilt.53, ss.780-784, 2008
dc.identifier.issn0003-9969
dc.identifier.otherav_88871545-b491-4afa-b187-85b425073c35
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/92640
dc.identifier.urihttps://doi.org/10.1016/j.archoralbio.2008.03.006
dc.description.abstractRecently, the IRF6 contribution that was reported for Van der Woude syndrome and non-syndromic oral clefts was extended to isolated tooth agenesis. Here we report the first study that tries to replicate this finding and we provide further evidence that IRF6 contributes to isolated tooth agenesis. Fifty-two sporadic tooth agenesis cases and their parents were studied. DNA samples were obtained from whole blood or saliva samples. Genotyping was performed by TaqMan assays. Linkage disequilibrium analysis and transmission distortion of the marker alleles were performed. A haplotype involving the most 5'IRF6 markers was associated with sporadic tooth agenesis (p = 0.006). An association could still be seen when only cases with at least one missing incisor (p = 0.01) and cases with at least one missing premolar (p = 0.004) were included in the analysis. (C) 2008 Elsevier Ltd. All rights reserved.
dc.language.isoeng
dc.subjectKlinik Tıp (MED)
dc.subjectSağlık Bilimleri
dc.subjectDİŞ HEKİMLİĞİ, ORAL CERRAHİ VE TIP
dc.subjectKlinik Tıp
dc.subjectTıp
dc.subjectDiş Hekimliği
dc.titleEvidence of linkage disequilibrium between polymorphisms at the IRF6 locus and isolate tooth agenesis, in a Turkish population
dc.typeMakale
dc.relation.journalARCHIVES OF ORAL BIOLOGY
dc.contributor.departmentPennsylvania Commonwealth System of Higher Education (PCSHE) , ,
dc.identifier.volume53
dc.identifier.issue8
dc.identifier.startpage780
dc.identifier.endpage784
dc.contributor.firstauthorID48316


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