dc.contributor.author | Onal, Armagan | |
dc.contributor.author | Sagirli, Olcay | |
dc.contributor.author | Sensoy, Demet | |
dc.date.accessioned | 2021-03-04T17:52:26Z | |
dc.date.available | 2021-03-04T17:52:26Z | |
dc.identifier.citation | Sagirli O., Onal A., Sensoy D., "LC assay of eletriptan in tablets and in vitro dissolution studies", CHROMATOGRAPHIA, cilt.68, ss.269-273, 2008 | |
dc.identifier.issn | 0009-5893 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_87c23d2a-5ebf-4155-9211-704dd38513aa | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/92175 | |
dc.identifier.uri | https://doi.org/10.1365/s10337-008-0673-8 | |
dc.description.abstract | Eletriptan (ELT) is a new selective serotonin agonist approved for the treatment of acute migraine headaches. A simple and rapid liquid chromatographic method was developed and validated for the assay of ELT in tablets. Chromatography was carried out on a 250 mm x 4.6 mm C(18) column at 30 C. Acetonitrile-15 mM triethylamine solution (adjusted to pH 7.0 using concentrated o-phosphoric acid) (60:40, v/v) mixture was used as mobile phase at 1.0 mL min(-1) flow rate and UV detector was set at 225 nm. A linear response (r(2) = 0.9999) was observed in the range of 0.1-1.6 mu g mL(-1). The method showed good recoveries (100.08 %) and the RSD values for intra- and inter-day precision were 0.78-1.93 and 1.10-2.15%, respectively. The method can be used for quality control assays and in vitro dissolution studies of ELT in tablets. | |
dc.language.iso | eng | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Temel Tıp Bilimleri | |
dc.subject | Biyokimya | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Sitogenetik | |
dc.subject | Analitik Kimya | |
dc.subject | Temel Bilimler | |
dc.subject | Temel Bilimler (SCI) | |
dc.subject | BİYOKİMYA VE MOLEKÜLER BİYOLOJİ | |
dc.subject | Kimya | |
dc.subject | KİMYA, ANALİTİK | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Biyoloji ve Biyokimya | |
dc.subject | BİYOKİMYASAL ARAŞTIRMA YÖNTEMLERİ | |
dc.title | LC assay of eletriptan in tablets and in vitro dissolution studies | |
dc.type | Makale | |
dc.relation.journal | CHROMATOGRAPHIA | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 68 | |
dc.identifier.startpage | 269 | |
dc.identifier.endpage | 273 | |
dc.contributor.firstauthorID | 65637 | |